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Health Issues That Affect German Shepherd Life Expectancy German Shepherds are at their peak between 2 and 6. The German Shepherd is at its best in terms of mental and physical sharpness. They are more at risk of developing illnesses of the musculoskeletal system and other health conditions that can affect their lifespan. Working line German Shepherds usually lead more active lifestyles than show line counterparts. They require a nutritious diet to support their high activity levels and exercise demands. Cushing's Disease German Shepherds are susceptible to s