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ADHD Treatment For Adults - Stimulant Medication Stimulant medicines like methylphenidate or dextroamphetamine are typically considered the first-line therapy for adult ADHD. These drugs balance and boost levels of brain chemicals known as neurotransmitters. Antidepressants and nonstimulant medications like atomoxetine can be prescribed if stimulants aren't appropriate for the patient due to other health issues or adverse reactions. These medications have a slower effect than stimulant