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In this study, a purpose-driven design of amphiphilic aerogel being employed as the enzymes-immobilization substrate to form the multienzyme complex (MEC) had been shown. The aerogel was synthesized only by a single polymer poly(vinyl liquor) (PVA) as well as a surface modulator maleic acid (MA), the incorporation of which tunes the outer lining wettability. The use of the amphiphilic aerogel can do favor for multienzyme immobilization, cons