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ADHD Treatment For Adults Stimulants like methylphenidate and amphetamine increase the levels of certain brain chemicals. Nonstimulants like atomoxetine or antidepressants perform slower than stimulants but they could be as effective. Complicating conditions can impact the effectiveness to ADHD medications. Physicians should treat the most severe symptoms of any comorbid disorder first, then monitor whether the ADHD symptoms improve. Medication The most commonly used method of treatment is medication. treatment option for adult