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Untreated ADHD in Adults Can Lead to Feelings of Worthlessness and Depression Untreated ADHD can lead to chronic underachievement and depression. This is especially evident when they fail to meet their professional and personal goals. Diagnoses can be difficult to make when there are commonalities in symptoms between ADHD and depression. Recognizing the symptoms is the first step in seeking treatment. 1. Feelings of Inadequacy Many people with untreated ADHD or depression co-occurring with it feel a sense of inadequateness and desperation. They may