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A gene cluster associated with neutrophil-mediated immunity was reduced at baseline in JNJ-55920839 responders, substantiated by lower neutrophil counts in responders. An IFN-I signature was suppressed by JNJ-55920839 treatment versus untreated blood to a greater extent in responders before dosing. These signatures may enable enrichment for treatment responders when using IFN-I-suppressing treatments in SLE. These signatures may enable enrichment for treatment responders when using IFN-I-suppressing treatments in SLE.Nerve transfer surgery