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Conclusions Only the new Index26 performed at a level comparable to the very strongest established formulas. All other new formulas had lower performance than was claimed in the original publications, underscoring that independent verification of new formulas is indispensable.Infective endocarditis (IE) is defined as infection of the endocardial surface of the heart which may involve heart valve, mural endocardium or septal defect. It's a disease with high morbidity and mortality without prompt treatment with antibiotics. Janeway lesions,