https://www.selleckchem.com/pr....oducts/Cisplatin.htm
58) h; AUClast = 250.25 (± 103.76) h*μg/mL; CL = 0.18 (± 0.1 L/h/kg. In CSF, pexidartinib was either quantifiable (n = 2), with Cmax values of 16.1 and 10.1 ng/mL achieved 2-4 h after plasma Tmax, or undetected at all time points (n = 2, LLOQCSF = 5 ng/mL). CONCLUSION Pexidartinib was well-tolerated in NHPs, with no Grade 3 or Grade 4 toxicities. The CSF penetration of pexidartinib after single-dose oral administration to NHPs was limited.PURPOSE To gain more knowledge about the mechanism (i.e., mediators) of resistance exercise (RE
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