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Consequently, assumptions on the transport system in endothelial cells are based on findings in polarised epithelial cells, although recent studies have highlighted differences in the endothelial system. This review highlights aspects of the vesicular trafficking machinery in brain endothelial cells, including recent findings, limitations, and opportunities for further studies. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Bacteria within biofilms are more resistant to antibiotics and