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The analysis of the seasonal dynamics of HEV seroprevalence in pregnant women in the period from February to September 2019 showed a tendency towards an increase in the values of the positivity coefficient of specific IgM antibodies by the beginning of the autumn. Antibodies to HEV were detected with highest frequency in women from Osh region. A high risk of HEV infection for pregnant women in the surveyed region had been shown. A high risk of HEV infection for pregnant women in the surveyed region had been shown. The only currently avail