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KGaA, Weinheim.BACKGROUND Platelet-rich plasma (PRP) is an emerging orthobiologic treatment for musculoskeletal conditions like osteoarthritis. Two studies have demonstrated the influence of longer duration exercise on PRP composition, but no study has ever explored the impact of high intensity interval exercise (HIIE) on PRP content. OBJECTIVE To quantify cellular and growth factor content changes in PRP after 4 min of HIIE. DESIGN Controlled laboratory pilot study. SETTING Academic sports medicine center. PARTICIPANTS Ten healthy volunt