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Atopicdermatitis (AD) has been linked to systemic infections in adulthood, but large-scale studies are few, and potential associations are unclear. To examine whether adults with AD have increased risk of developing systemic infections leading to hospital-based management. Nationwide register-based cohort study including all Danish adults from 1995 through 2017. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated by using Cox models. A total of 10,602 adults with AD (median age, 29.8y; interquartile range, 22.6-44.8) a