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This article is protected by copyright. All liberties reserved.Dietary interventions, including a low-protein diet (LPD) and methionine (Met) constraint, have shown longevity, anti-aging and metabolic health results. We formerly reported that the LPD has a renoprotective impact against diabetic kidney disease (DKD) in rats with type 2 diabetes and obesity. Nevertheless, it's not clear perhaps the beneficial effectati