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Thus, these nanoscopic particles combine selectivity for human brain capillary endothelial cells with great sensitivity of Xe Hyper-CEST MRI and might be a potential MRI tool in brain diagnostics. © 2020 The Authors. Published by WILEY-VCH Verlag GmbH Co. KGaA, Weinheim.Epithelial to mesenchymal transition (EMT) is integral for cells to acquire metastatic properties, and ample evidence links it to bioorganic framework of the tumor microenvironment (TME). Hydroxymethyl-functionalized 3,4-ethylenedioxythiophene polymer (PEDOT-OH)