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5%]). Survival analysis demonstrated results in favor of ePLND (unweighted hazard ratio 0.77 [95% confidence interval 0.59-1.01], p = .056; weighted hazard ratio 0.75 [0.56-0.99], p = .044). The causal mediation analysis confirmed the total effect of 0.77 (0.71-0.82). After disentangling this total effect into an indirect effect (via detection of nodal disease and potential adjuvant therapy) and a direct effect (via removal of occult micrometastases), we identified an even more protective direct effect of 0.69 (0.63-0.75). Our results not only indicate the
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