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Safety monitoring will be performed using scales for side effect, serious adverse events recording, and laboratory tests. Conclusion This trial is expected to clarify the efficacy of SFN in improving prodromal symptoms, and its role in decreasing the risk and conversion rate of psychosis among CHR subjects. The results will also provide solid evidence about the efficacy and safety of SFN in CHR population. Potential challenges and their solutions in performing the present trial are discussed.The fruit fly Drosophila melanogaster can be us