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ADHD Treatment For Adults The stimulants methylphenidate and amphetamine increase the levels of certain brain chemicals. Nonstimulants, such as atomoxetine and antidepressants, operate more slowly than stimulants but may also be helpful. Complicating conditions often affect the response to ADHD medications. The most severe symptom from any comorbid condition should be treated first. Then, the physician must be able to determine if ADHD sympto