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This short article is protected by copyright. All liberties reserved.Dietary interventions, including a low-protein diet (LPD) and methionine (Met) restriction, have shown durability, anti-aging and metabolic health impacts. We previously stated that the LPD has a renoprotective impact against diabetic kidney disease (DKD) in rats with type 2 diabetes and obesity. Nevertheless, its uncertain whether or not the advantageous effect of the LPD is mediated by low-Met consumption or just how Me