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9% at vehicle impact speed of 30 km/h, 23% at 50 km/h, 50% at 60 km/h, and 90% at 80 km/h. Rider age is also significantly associated with a higher risk of severe and fatality injury. The e-bike impact speed is not significantly associated with the severe and fatality risk in e-bike side collisions.Conclusions The findings of this study provide meaningful insights to formulate effective policies especially for speed limit management to improve the safety of e-bikes.Solid microneedles (MNs) represent a useful tool for enhancing skin permeability by creating