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ADHD Treatment For Adults Stimulants like methylphenidate, amphetamine and other brain chemicals can aid in increasing levels. Nonstimulants, like atomoxetine and antidepressants, operate more slowly than stimulants but may also be helpful. Comorbid conditions often affect the effectiveness of ADHD medication. The most severe symptoms from any comorbidity should be treated first. Then, the physician should monitor whether ADHD symptoms improve. Medication Medication is the most popular fo