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Strikingly, recruitment associated with the BTR complex to telomeres in a PML-independent fashion bypasses the need for PML in the ALT pathway, suggesting that BTR localization to telomeres is sufficient to maintain ALT activity. © 2020 Loe et al.; posted by Cold Spring Harbor Laboratory Press.Primary lateral sclerosis (PLS) is an unusual neurodegenerative condition in the upper motor neurone extreme of the spectrum of engine neurone infection. The analysis is clinical and in line
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