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ADHD Treatment For Adults Stimulants like methylphenidate and amphetamine help boost levels of certain brain chemicals. Nonstimulants, such as antidepressants and atomoxetine, work slower than stimulants, but can also be beneficial. Comorbid conditions can alter the effectiveness to ADHD medication. Physicians should treat the most severe symptom of any comorbid disorder first, then monitor whether the ADHD symptoms improve. Medication Adults suffering from ADHD are