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We evaluated the safety and activity of pembrolizumab in conjunction with trastuzumab and chemotherapy in first-line HER2-positive metastatic oesophagogastric (gastric, oesophageal, or gastroesophageal junction) disease. Practices This study ended up being an investigator-initiated, open-label, non-randomised, single-arm, solitary center, stage 2 trial in clients elderly 18 years or older with HER2-positive metastatic oesophagogastric cancer. Eligible clie