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Epigenetic modifications are affected by the external environment. Many of these adjustments are influenced by our own life-style. Unusual circadian rhythm and low-quality of rest have now been proven to increase the risk of building T2DM along with other metabolic disorders. Here, we attempt to offer an extensive information of shared relationships between epigenetic regulation, circadian rhythm, aging process and emphasize brand-new evidences that show possible healing advance in the area of chrono-medicine which is more essentia