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Indonesian version of HIV Symptom Index is reliable (cronbach alpha 0.76) and valid (multitrait correlation 0.4) for measuring symptoms of HIV/AIDS patients. The most common symptom is fatigue (55.7%), followed by insomnia (43.3%), dizziness and lightheadedness (42.3%), skin problems (42.3%), and pain, numbness, or tingling in the hands or feet (39.2%). Indonesian version of HIV symptom Index is reliable and valid to measure symptoms of HIV/AIDS patiens objectively. Indonesian version of HIV symptom Index is reliable and valid to mea