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In conclusion, our data suggested that PP effectively inhibited cell proliferation through the ROS-mediated AKT-dependent signaling pathway in CRC, further providing evidence for the use of PP as an antitumor agent.Globally, ecosystem-based marine spatial planning has become a useful instrument to coordinate the planning of different authorities. This, for balancing different requirements when managing marine areas and space. In the planning process, ecology is setting limits to which human activities are acceptable to the society. The u