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It is hoped that this article will also set a stage for expanded efforts in the identification, characterization, and functional interrogation of plant sirtuins; and the development and exploration of their chemical modulators (activators and inhibitors) in plant research and agriculture. Iron (Fe) is an essential micronutrient for plant life and development. However, in soil, Fe bioavailability is often limited and variable in space and time, thus different regions of the same root system might be exposed to different nutrient provisi