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Smokers with this belief reported an increased interest in quitting (AOR 4.6, 95 % CI1.7-12.4). Overall, 49 % of smokers and 42 % of vapers reported increased interest in quitting due to the pandemic; 24 % and 20 %, respectively, reported attempting to quit since the pandemic. However, 35 % of smokers and 27 % of vapers reported increasing smoking and vaping, respectively, during the pandemic. Most patients with OUD believed that smoking and vaping increased their vulnerability to COVID-19, half reported increased interest in quitting,