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Behavioral and social science theories/models have been gaining attention in sports injury prevention. To investigate the potential of the Theory of Planned Behavior in explaining running-related injury preventive behavior. Six-month prospective cohort study based on data gathered from a randomized controlled trial. From a total of 1512 invited trail runners, 232 were included in this study. Preventive behaviors and their determinants were assessed at baseline and two and six months after baseline. Five-point Likert scales were used to