https://www.selleckchem.com/pr....oducts/itacitinib-in
Rheumatoid arthritis is an autoimmune systemic disorder causing pain, swelling, stiffness, and disability in various joints. This work was designed to evaluate the effect of sitagliptin and tofacitinib on Janus kinase (JAK)/signaling transducer and activator of transcription (STAT) and toll like receptor (TLR-4)/nuclear factor kappa B (NF-κ signaling pathways in adjuvant induced arthritis in rats. Severity of arthritis was evaluated and serum was analyzed for inflammatory mediators. The mRNA and protein expression level o
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