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6% and 29.6%, respectively. CONCLUSION Structure-based virtual screening using a molecular docking approach is a useful method for the identification of new transsialidase inhibitors. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.BACKGROUND Curcumin, as the substantial constituent of the turmeric plant (Curcuma longa), plays a significant role in the prevention of various diseases, including diabetes. It possesses ideal structure features as enzyme inhibitor, including a flexible backbo