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management of adverse effects in medical practices, demonstrating the importance of patient monitoring for the possibility of cytomegalovirus reactivation in heavily pretreated myeloma patients. To report a rare case of a hepatitis B patient who developed the Stevens-Johnson syndrome (SJS) secondary to tenofovir use. A 61-year-old woman presented with complaints of jaundice, difficulty in swallowing, and burning sensation all over the body along with erythematous polymorphic rash on the face, upper limbs, and trunk. She was diagnosed wit