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First Line Treatment For ADHD in Adults Certain people with ADHD are able to use medication to manage their symptoms. Stimulants, like amphetamine and methylphenidate work by increasing activity in the brain regions that regulate attention and behaviour. Other medications, such as the non-stimulant drug atomoxetine and certain antidepressants perform differently, but are still effective. Patients who are taking medication should visit their GP regularly to ch