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Untreated ADHD in Adults Can Lead to Feelings of Worthlessness and Depression Untreated ADHD can result in chronic underachievement and depression. This is particularly the case when they fail to meet their professional and personal goals. It can be difficult to make when there are overlaps in symptoms between ADHD and depression. Identifying the symptoms is a good first step in seeking treatment. 1. Feelings of inadequacy Untreated ADHD and co-occurring disorders of depression can trigger feelings