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The Patient Health Questionnaire-9 (PHQ-9) and the Generalized Anxiety Disorder-7 (GAD-7) are two commonly used screening tools for depression and anxiety, respectively. Despite the widespread use of these instruments, researchers have yet to examine whether scores may differ as a function of gender identity or sexuality orientation. Using data from the 2018 and 2019 National Healthy minds study (N=46,672), the present study tested each instrument for measurement invariance across 16 gender and sexual minority groups. Multigroup structur