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reatitis and the combination of chemotherapeutic agents may increase the risk of drug-induced pancreatitis. The heart transplantation is the most important treatment for patients with end-stage severe heart disease who failed to conventional therapy. Post-transplant lymphoproliferative disorder is the second most common malignancy in heart transplant recipients. However, primary central nervous system lymphoma (PCNSL) after heart transplantation is an extremely rare condition. This report described a 53-year-old male who was diagnosed as PCNSL 17 months aft