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In Egypt, circulatory system diseases are responsible for one-third of the annual deaths. Stroke comes 3rd after heart diseases and liver diseases. Stroke includes two types ischemic and hemorrhagic. The sirtuins (SIRTs) are a family of histone deacetylases that are nicotinamide adenine dinucleotide (NAD) dependent. They are activated under conditions of decreased cellular energy stores and are involved in the control of several physiological processes. To measure theplasma levels of SIRT1 in acute cerebrovascular stroke, toassess its
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