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e studies of compound optimization, in vivo safety and efficacy, as well as of the specific mechanisms of action are however required. the objective of this study was to evaluate the incidence of Chronic Intervillositis of Unknown Etiology (CIUE) at our institution and to report on the pregnancy outcomes based on severity of lesions. retrospective cohort study including 29889 perinatal specimens from 27968 patients. The pathology database at our institution was queried for the keywords "intervillositis" and "CIUE" between February 2006