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A new core-shell structured nanomaterial based on Fe3O4 nanoparticles and 2,3-dialdehyde nanocrystalline cellulose (DAC) coating and its high efficiency in the preconcentration of glycoproteins were described in this work. DAC was obtained after the periodate oxidation of nanocrystalline cellulose to form aldehyde groups; then, Fe3O4 nanoparticles were coated with DAC, which were further attached to 4-aminophenylboronic acid (PBA) to form PBA-functionalized magnetic core-shell structured materials (Fe3O4@DAC-PBA). The oxidation of cellul