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Importantly, the correlation between 14-3-3ε expression, PIs sensitivity and protein load was observed in primary MM cells from two independent datasets; and its lower expression was associated with poor outcome in MM patients receiving a bortezomib-based therapy. Altogether these observations suggest that 14-3-3ε is a predictor of clinical outcome and may serve as a potential target to modulate PIs sensitivity in MM. Copyright © 2020 American Society of Hematology.The interplay between life sciences and advancing technology drives a c
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