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To determine frequency of Muscle Weakness in Non-Hypoxemic COPD out-patients and Comparison with age matched non-COPD Controls. This cross-sectional study was conducted at OPD of Ojha Institute of Chest Diseases and Medicine, Dow University of Health Sciences, Karachi, Pakistan, during the period 8 September 2019 till 30 May 2020. Patients of both genders aged 25-70 years who were satisfying GOLD criteria for COPD and having SpO ≥ 94% were included. An age matched control group was added as control. Hand Grip Strength (HGS) and Chair to