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To further develop prosthetic devices that are successful for long-term use, we discuss animal models for developing new surgical techniques and device testing. As an economic/ethical alternative to genetic modification, animal models of drug-induced outer retinal degeneration are discussed.Significance. Combined, the presenting perspective highlights the crucial issues for more successful retinal implants. Creative Commons Attribution license.We investigated the prognostic significance of ataxia telangiectasia mutated (ATM) single nucle