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These observations have potential importance in the application of meta-analyses to many common and serious diseases, as well as genomics and precision medicine, including OUD. These data, from genetic studies, suggest biases are different in meta-analyses of case-control and cohort studies, perhaps due to greater selection bias in case-control studies. These observations have potential importance in the application of meta-analyses to many common and serious diseases, as well as genomics and precision medicine, including OUD. This stud