https://www.selleckchem.com/pr....oducts/gsk2830371.ht
In the small intestine of HFHC-NASH rats, thicker intestinal wall with more collagen fibres, increased Ces1 activity and up-regulated P-gp protein decreased the permeability of simvastatin, accelerated the hydrolysis of simvastatin and promoted the efflux of simvastatin acid respectively. In the liver of HFHC-NASH rats, higher hepatic P-gp expression accelerated the hepatic elimination of simvastatin. Altered histology, Ces1 activity and P-gp expression in the small intestine/liver were identified to be the major contributing factors
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