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First Line Treatment For ADHD in Adults Some people with ADHD find medication helps to manage their symptoms. Drugs like methylphenidate and amphetamine help by enhancing brain activity in the areas that control attention and behavior. Other medications, such as the non-stimulant drug atomoxetine and antidepressants that work differently, but they are effective. Regular visits to the GP is recommended for patients who are taking medication. They can adjust dosages and monitor the