https://www.selleckchem.com/pr....oducts/epalrestat.ht
BACKGROUND Hyperfiltration (HF) occurs early in diabetes or obesity (O-associated renal disease. Alterations of glomerular filtration rate (GFR) in childhood OB remain unclear. OBJECTIVES To compare the prevalence of GFR alterations and its association with uric acid in children and adolescents with type 1 diabetes (T1D) vs overweight (OW)/OB. METHODS Cross-sectional study of 29 youths (aged 13 ± 2 years) with T1D (disease duration 7 ± 3 years) and 165 with OW/OB (aged 11 ± 3 years). Patients with an albumin-creatinine ratio 3.
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