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Copyright © Sun et al.Plantamajoside (PMS) has been confirmed to have anticancer results and is the key substance of Plantago asiatica. The goal of the present study was to explore the effects of PMS on cancerous melanoma and its own molecular mechanisms. The malignant melanoma cell line A2058 was addressed with different levels of PMS (0, 20, 80 and 160 µg/ml) for 24, 48 or 72 h, followed closely by mobile viability recognition utilising the Cell Counting Kit-8 assay. The current outcomes recommended that PM