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Changes in fMRI are evident in PWH without perceived neuropsychiatric issues changing cART. fMRI is a useful tool in assisting to elucidate the root pathogenic mechanisms of cART-related neuropsychiatric effects.The reason for this research was to assess entire brain and local habits of cerebrovascular reactivity (CVR) abnormalities in HIV-infected women using quantitative whole mind arterial spin labeling (ASL). We hypothesized that HIV-infected females would show reduced local brain CVR despite viral suppression.