https://bulevirtideinhibitor.c....om/a-digital-applyin
We report that inhibition of FGF/FGFR signaling impairs sphere-forming ability of PDAC in vitro, and knocking down FGFR1 and FGFR2 decreased their particular tumorigenesis capabilities in vivo. Mechanistically, we demonstrated that SOX2 is down-regulated upon loss of FGFR signaling. The overexpression of SOX2 in SOX2-negative cells, which normally don't display stemness abilities, is sufficient to cause spheroid formation. Additionally, we discovered that AKT phosphorylation ha
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