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ADHD Treatment For Adults Stimulants like methylphenidate and amphetamine can boost the levels of certain brain chemicals. Nonstimulants, such as atomoxetine and antidepressants, operate slower than stimulants but may also be helpful. The comorbidity of conditions can affect the response to ADHD medications. Physicians should address the most severe symptoms of any co-occurring disorder first, and then check to see if the ADHD symptoms improve. Medication The most commonly used method of treatmen